Cerro Porteño 1-1 Independiente Medellín
Colombia's Independiente Medellín made a promising start to their campaign after picking up a useful point again Cerro Porteño of Paraguay. Felipe Pardo put Independiente ahead after 17 minutes, springing the offside trap to slot home and to stun the vocal home crowd in Asunción. Cerro Porteño rescused a point in the second half, when Pablo Zeballos levelled matters 11 minutes into the second half when his cross come shot somehow found it's way into the back of the net
Club Nacional 0-2 Once Caldas
São Paulo 2-0 Monterrey
Once Caldas of Colombia made a marvellous start to their 2010 campaign with a fantstic 2-0 away at Club Nacional of Paraguay. Jamie Castrillón put Once ahead half way through the first half when he was left unmarked and able to shoot home. The second came twenty minutes into the second half when Once sprung the offside trap and Danny Santoya was on hand to finish the move off. São Paulo set off on the right note when a 2-0 home victory over Mexican invitees Monterrey. Washington put São Paulo ahead with 13 minutes on the clock when he was in the right place at the right time and the big forward was on hand to double the lead with 14 minutes left after being left unmarked at the back post to tap in a flick on from Hernanes.
Bolívar 1-3 Alianza Lima
Estudiantes 5-1 Juan Aurich
Peru's Alianza Lima made a perfect start with an impressive 3-1 win at Bolívar. Jose Fernández broke the deadlock with 72 minutes on the clock and then doubled the lead two minutes later after getting the luck of the bounce. William Ferreira pulled a goal back for Bolívar from the spot with a minute to go and as the home side pressed for an equaliser Johnnier Montaño raced clear to finish things off for the visitors. The holders began the defence of their title with an emphatic win of Juan Aurich of Peru. The visitors made a nervy start and were a goal down in 7 minutes when Mauro Boselli converted from the spot. Credit to the visitors though as they found their feet and were full value for their equaliser on 34 mintues when Luis Tejada struck to stun the home fans. Estudiantes were ahead again by half time when German Ré headed home and then disaster for the Peruvians when Roberto Guizasola was sent off just before the break. Against the 10 men Estudiantes turned up the heat, Boselli completed his hat-trick to put the game same and Leandro González put the icing on the cake in the last minute after his shot took a wicked deflection.
Lanús 0-2 Libertad
Blooming 1-3 Universitario
Argentina's Lanús slumped to a surprise home defeat against Libertad of Paraguay but their defensive failings of the homeside that contributed to their defeat. The first mistake allowed Rodolfo Gamarra to put Libertad ahead after 66 minutes and eight minutes later the Lanús defenders hadn't learnt from their earlier errors and Pablo Velazquez doubled the lead to take the points back to Asunción. In Santa Cruz, Universitario of Peru made a great start to their campaign with victory in Bolivia against Blooming. All the goals came in the second half, Carlos Orejuela put Universitario ahead eight minutes into the half after springing the offside trap and Rodolfo Espinola doubled the advantage 15 minutes from time after arriving at the back post to fire home. David Villalba piledriver from 25 yards pulled a goal back for Blooming with two minutes left but it was too little too late for the Bolivians.
Cerro 2-0 Deportivo Quito
In only their second ever appearance in the compeition Cerro made a winning start against Deportivo Quito in Montevideo. Cerro took the lead with 20 minutes on the clock when Claudio Dadómo finished at the second attempt. The second goal was bizarre, Deportivo goalkeeper Ibarra went walkabout and Rodrigo Mora pounced on the ball to slot home.
Banfield 2-1 Morelia
Nacional 3-2 Deportivo Cuenca
Argentina Apetura champions Banfield made a winning start against much fancied Morelia of Mexico. After a goal less first half the game came alive in the 52nd minute when Morelia's Adrian Aldrete was sent off for using an elbow. Three minute later, the home side were ahead a quick break from Banfield and James Rodriguez arrrived at the back post to head home. Banfield doubled their lead 11 minutes from time when Roberto Battion headed home from a corner to put the points in the bag. Luis Rey managed to grab a consolation from Morelia in injury time, arrriving at the back post to head home. Nacional of Montevideo began their campaign with a hard fought victory over Deportivo Cuenca of Ecuador. It was the visitors who took the lead through Jose Granda after 25 minutes, a lead they would hold until half time. Nacional came out of the blocks quickly after half time and were level within a minute of the restart when Mario Regueiro struck. A second from Reguerio put Nacional ahead 20 minutes into the second half but the lead lasted only three minutes before Luis Escalada levelled again. With the game heading towards a draw, Nacional built the pressure and after a a foul gave them a penalty with five minutes to go, Óscar Morales converted to give the home side maximum points.
Vélez Sársfield 2-0 Cruzeiro
Last years runners up Cruzeiro finished with nine men as they fell to defeat at Vélez Sársfield. Gilberto was the first to go with only two minutes on the clock for a high challenge. Three minutes later the ten men were behind when Santiago Silva headed home. The mountain got a lot larger for Cruzeiro when Gil was dismissed for a second yellow card 8 minutes before half time. The 9 men went close just before half time but the second half was all Vélez and they doubled the lead 13 minutes from time when Juan Martinez was on hand to tap in.