River Plate Montevideo 4-1 Vitória
Alianzia Atlético Sullana 2-2 Fluminense
Vélez Sársfield 3-2 Unión Española
Internacional 1-1 Universidad de Chile
Botafogo 2-0 Emelec Guayaquil
Liga de Quito 4-0 Lánus
San Lorenzo 3-0 Cienciano Cusco
Cerro Porteño 2-0 Goiás
River Plate have one foot in the last 8 after a comprehensive win over Vitória in the Centenario. Jorge Córdoba struck twice to put the hosts 2 up before Wallace pulled one back for Vitória. River though enhanced their dominance with two strikes in the last 10 minutes, Andrezinho and Jorge Rodríguez giving River a three goal cushion to take back to Brazil. Fluminense put their poor Série form behind them as they grabbed an away dray in Peru against Alianza. Luiz Alberto put Fluminense ahead as early as the sixth minute but they were pegged back by Saulo Aponte just after half time before Marcio Valverde put Alianza ahead with 20 minutes to go. Fluminense showed some of the character that has been missing from their league performances and grabbed an equalizer from Dario Conca to take the tie back to the Maracaña all square.
Vélez Sársfield staged a remarkable comeback to give them a slender advanatge to take to Chile next week. Hernan López put Vélez ahead but David Ramirez levelled things at half time. Raul Estevez put Unión ahead on the hour and going into injury time it looked like they would secure a famous victory but a heartbreaking own goal from Diego Rosende levelled things and a still shocked Unión conceded again deep in injury time. Rolando Zarate with a cruel winner for Vélez. The holders Internacional joined the competition at this stage and began the defence of their trophy at home to Universidad. The holders were stunned when Walter Montillo put Universidad ahead after 25 minutes but gave themselves a fighting chance in next week's second leg when Kleber levelled 13 minutes from time.
Botafogo were the other Rio club in action to put their poor league form behind them as they defeated Emelec Guayaquil at the Engenhão. Renato put Botafogo ahead right on half time before Andre Lima added a second twenty minutes into the second half to give Botafogo and advantage to take back to Ecuador. Liga de Quito also put a foot in the last eight after sweeping aside Lánus. The 2008 Libertadores winners were two up inside 7 minutes, Claudio Bieler with both goals. Bieler then completed a hat trick after 25 minutes when he converted from the spot. The Lánus players lost the plot late in the game and lost Santiago Hoyos and Adrian Peralta to red cards before Edison Méndez wrapped things up from the spot.
The 2002 winners, San Lorenzo, and 2003 winners, Cienciano, met up in Argentina and it was San Lorenzo who came out on top to take a big advantage back to Peru. The hosts were two up by half time, Bernardo Romeo scoring after 12 minutes before Gonzalo Rovira doubled the advantage 10 minutes before half time. Romeo claimed a second goal in the second half to leave Cienciano a mountain to climb in the second leg. After scraping through on penalties last week, Goiás made 4 changes from the team that defeated Corinthians as they fell to defeat in Paraguay against Cerro Porteño. Julio Dos Santos put Cerro Porteño ahead 8 minutes into the second half before Diego Herner doubled the lead thirteen minute later. Goiás then lost Vitor to a red card, and they will have all work to do to claw the defecit back next week.
The second legs all take place next week.